Tretinoin AlphaBisabololGel （50mg 100mg/100g） 1.Formulation I.Tretinoin（BASF）......................................0.05g LutrolE400[1].........................................5.0g CremophorRH40[1]...............................6.0g Butylhydroyto luene.................................0.04g （-）alpha-Bisabolol,natural（BASF）..............0.1g
II.Water.....................................................70.3g Preservatives..............................................q.s. III.LutrolF127[1].......................................18.5g 2.Manufacturing AddsolutionIIslowlyto theclearsolutionIatabout40C.Heatto about50Canddissolveabout14gofIIIinthecombinedsolutionI/
II. Coolto about6Canddissolvetheresto fIII.Maintaincooluntiltheair bubblesescaped. 3.Propertiesofthegel Aclearyellowishgelwasobtained. 4.Chemicalstability（20–25C,dark） 0Months6Months12Months Tretinoincontent100%100%96% Therewasnolossofalphabisabololduringthese12months. 5.Remark Itisimportantto protectthisformulationagainstlightto avoidthe isomerizationanddegradationoftretinoin.
关键字：tretinoin alpha bisabolol
