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HydrocortisoneAqueousGels (1%) 1.Formulations No.1No.2 I.Hydrocortisoneacetate.................................1.0g1.0g II.LutrolE400[1]............................................10.0g– CremophorA25[1].............................................–15.0g CremophorRH40[1]....................................5.0g20.0g III.Carpopol940(Goodrich)...............................0.5g– Water.........................................................49.5g– IV.Preservative....................................................q.s.q.s. Water.........................................................26.0g64.0g V.Triethanolamine.............................................0.8g– Water............................................................7.2g– 2.Manufacturing FormulationNo.1: Suspend IinthemixtureIIat70C.PreparesolutionII,dilutewiththe solutionIV,heatto 70C,andaddslowlyto thehotmixtureI/ II.Add solutionVandcontinueto stiruntilthegeliscool. FormulationNo.2: Suspend IinthemixtureIIat70C.PreparesolutionIV,heatto 70C andaddslowlyto thehotmixtureI/ II.Continueto stiruntilthegeliscool. 3.Properties Clearcolourlessgels.
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