Crospovidone Water Dispersible Tablets

CrospovidoneWaterDispersibleTablets （1000mg） 1.Formulation I.CrospovidoneM（BASF）.........................1000g Aerosil200[4]...........................................50g II.Sucrose,crystalline.................................250g Saccharinsodium........................................5g Flavours..................................................2-3g Water......................................................380g III.Magnesiumstearate[2]...............................5g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass throughasieve,mixthedry granuleswithIIIandpresswithlowcompressionforce. 3.Tabletproperties Weight...............................................1280mg Diameter...............................................20mm Form...................................................biplanar Hardness................................................103N Disintegration......................................1–2min Friability..................................................0.6% 4.Remark Thedosagemaybeincreasedto 2000mgCrospovidonebyincreasing thetabletweightto 2600mg.