IbuprofenTablets
（400mg）,DC
1.Formulations
Ibuprofen（Francis）...................................400g Aerosil200[4]............................................4g Ludipress[1]...........................................342g KollidonCL[1]............................................8g Magnesiumstearate[2]...............................8g 2.Manufacturing（Directcompression）
Passibuprofenandmagnesiumstearatethrougha200μmsieve,mix
withtheothercomponentsandpresswithmediumcompressionforce.
3.Tabletproperties
Weight......................................................752mg Diameter....................................................16mm
Hardness.....................................................112N
Disintegration..........................................2–3min
Friability.......................................................0.4%
Dissolution,10min........................................82%
15min.........................................91%
4.Physicalstability（20–25C）
6Months8Months12Months
Hardness–121N120N
Disintegration–2–3min–
Friability–0.4%0.2%
Dissolution,10min85%–89%
20min87%91%88%
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