Glibenclamide（Glyburide）Tablets
（5mg）
1.Formulation
No.1No.2
Glibenclamidemicronized（Guidotti）................5.0g–
Glibenclamide.....................................................–5.0g Ludipress[1].............................................120.0g194.0g Magnesiumstearate[2].................................0.5g1.0g 2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieveandpresswithlow
compressionforce（about10kN）.
3.Tabletproperties
No.1No.2
Weight......................................................125mg201mg Diameter......................................................7mm8mm
Form........................................................biplanarbiplanar
Hardness......................................................80N107N
Disintegration............................................2-3min3–4min
Friability.....................................................<0.2%<0.1%
Dissolution（pH7.4）（10min）...........................50%–
（30min）...........................69%–
（60min）...........................75%–
4. Influence of the compression force on the physical tablet properties
（Formulation No. 2）
Compression force
Property 5 kN 10 kN 20 kN 25 kN
Hardness 47 N 107 N 158 N 191 N
Disintegration 2 – 3 min 3 – 4 min 3 – 4 min 5 min
Friability <0.1% <0.1% <0.1% <0.1%