Verapamil Spheronized Pellets for Sustained Release Coating

VerapamilSpheronizedPelletsfor
SustainedReleaseCoating （48%）
1.Formulation
IVerapamilHCI（BASF）..............................480g AvicelpH101[5]......................................300g KollidonVA64[1].......................................20g Aerosil200[4]...........................................25g Talc[10]..................................................175g IIWater......................................................400g 2.Manufacturing Granulatethemixture（I）inaDiosnagranulato rwithwater（II）andpass
thehumidgranulesthroughasieveof1.5mm.Formpelletsinaspheronizer
withtherotationspeedof300-400rpm.Drythepelletsinafluidized
bedandsievethrougha0.7mmsieveto eliminatethefineparticles.
3.Remark
Seealso“SustainedReleaseCoatingofVerapamilPellets”