DiclofenacSpheronizedPelletsfor SustainedReleaseCoating （30%） 1.Formulation I.Diclofenacsodium...................................300g AvicelpH101[5]......................................438g Granulac230[8]......................................237g KollidonVA64[1].......................................25g
II.Water............................................about580g 2.Manufacturing Granulatethemixture（I）inaDiosnagranulato rwithwater（II）andpress thehumidgranulesthroughasieveof1.5mm.Formpelletsinaspheronizer during10minwiththerotationspeedof380-420rpm.Drythepellets inafluidizeddbedat70C.
关键字：diclofenac heronized pellets
