AcetylsalicylicAcidTablets
（400mg）
1.Formulation
Acetylsalicylicacid,crystalline（Merck）......400g Ludipress[1].............................................99g Stearicacid[7]............................................1g KollidonCL[1]...........................................15g 2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieveandpresswithlow
compressionforce.
3.Tabletproperties
Weight.................................................516mg Diameter...............................................12mm
Form...................................................biplanar
Hardness..................................................90N
Disintegration........................................<1min
Friability...................................................0.4%
Dissolution,15min....................................84%
30min...................................97%
4.Chemicalstability
Sto ragetimeRT40C
0months100.0%100.0%
6months100.0%100.0%
12months98.4%100.0%
Thecontento ffreesalicylicacidremainedalwaysbelow0.2%.
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