乙酰半胱氨酸泡腾片Acetylcysteine Effervescent Tablets

1.Formulation
Acetylcysteine,crystalline（Merck）.............600g LudipressLCE[1]....................................400g Sodiumbicarbonate................................450g Tartaricacid,powder...............................350g Polyethyleneglycol6000,powder[6]..........75g Apartame（Searle）......................................25g Orangeflavour（Dragoco）............................q.s.
2.Manufacturing（Directcompression）
Mixallcomponents,pass throughasieveandpresswithmediumcompression
forceatamaximumof30%ofrelativeatmospherichumidity.
3.Tabletproperties
Weight................................................1975mg Diameter...............................................20mm
Form...................................................biplanar
Hardness..................................................97N
Disintegration......................................2–3min
Friability...................................................1.1%
BASF