Crospovidone Effervescent Tablets

CrospovidoneEffervescentTablets （1000mg） 1.Formulation I.Crospovidone,micronized......................1000g （KollidonCL-M,BASF） Citricacid................................................150g Aerosil200[4]...........................................25g II.Sucrose,crystalline..................................100g Saccharinsodium........................................1g Water.........................................................q.s. III.Magnesiumstearate[2]...............................5g Sodiumbicarbonate.................................125g Flavourmixture..........................................65g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass throughasieve,mixthedry granuleswithIIIandpresswithmediumcompressionforce. 3.Tabletproperties Weight...............................................1590mg Diameter...............................................20mm Form...................................................biplanar Hardness................................................111N Disintegration..........................................1min Friability...................................................0.4% 4.Remark Thedosagemaybeincreasedto 2000mgcrospovidonebyincreasing thetabletweightto 3200mg.