MultivitaminEffervescentTabletsII,DC
（3–4RDAofVitamins）
1.Formulations
No.1No.2
Thiaminemononitrate（BASF）.........................5.5g5.5g Riboflavin（BASF）...........................................5.5g5.5g Pyridoxinehydrochloride（BASF）...................6.5g6.5g Nicotinamide............................................60.0g60.0g CalciumD-panto thenate（BASF）...................30.0g30.0g Ascorbicacid,powder（BASF）....................200.0g200.0g Cyanocobalamin0.1%drypowder...............20.0g20.0g VitaminApalmitate
drypowder325000i.u./gCWD（BASF）........30.0g30.0g VitaminEacetatedrypowder50%.............110.0g50.0g Citricacid,powder..............................................–500.0g Tartaricacid,powder.................................400.0g–
Sodiumbicarbonate..................................500.0g500.0g Ludipress[1]..........................................600.0g500.0g Polyethyleneglycol6000,powder[6]............70.0g70.0g Saccharinsodium.........................................0.5g0.5g Cyclamatesodium.......................................40.0g40.0g Sucrose,crystalline...................................200.0g200.0g Fructo se..........................................200.0g200.0g Flavours（Firmenich）...................................100.0g100.0g 2.Manufacturing（Directcompression）
Mixallcomponents,sievethrougha0.8mmscreenandpresswithhigh
compressionforceatmaximum30%relativeatmospherichumidity.
3. Tablet properties
No. 1 No. 2
Weight ....................................................2200 mg 2495mg
Diameter ....................................................20 mm 20 mm
Form ........................................................biplanar biplanar
Hardness ......................................................98 N 197 N
Disintegration （water）................................1 – 2 min 2 min
Friability .......................................................1.0% 0.4%
4. Chemical stability of formulation No. 1 （after 12 months at 20–25 C;
HPLC）
Vitamin B1 ...................................................93%
Vitamin B6 ...................................................89%
Vitamin B12...................................................88%
Vitamin A ......................................................79%
All other vitamins .........................................> 95%
关键字：multivitamin effervescent tablets
