MultivitaminTabletCoreswith Beta-Carotene
（1–2RDAofVitamins）
1.Formulation
Vitaminmixture（BASF,see“Remark”）....270.2g Ludipress[1]..........................................69.1g Magnesiumstearate[2].............................3.3g 2.Manufacturing（Directcompression）
Passallcomponentsthrougha0.8mmsieve,mixandpresswithhigh
compressionforce.
3.Tabletproperties
Weight.................................................459mg Diameter...............................................11mm
Form..................................................biconvex
Hardness..................................................97N
Disintegration（water）..............................13min
Friability.....................................................0%
ContentuniformityofVitaminB1,
B2,B6andfolicacid................conformto DAB
4. Remark
The used vitamin mixture had the following composition:
Vitamin A acetate dry powder .....................1.27%
500000 i. u./g
Beta carotene dry powder BetaVit 10%......11.50%
Thiamine mononitrate..................................1.24%
Riboflavin ..................................................0.96%
Nicotinamide.............................................11.50%
Calcium D-panto thenate .............................1.91%
Pyridoxine hydrochloride .............................1.15%
Cyanocobalamin gelatin coated 1%.............2.86%
D-Biotin, 1% trituration ...............................1.91%
Folic acid ...................................................0.09%
Ascorbic acid............................................38.20%
Vitamin D3 dry powder 100000 i. u./g..........0.76%
Vitamin E acetate dry powder 50 DC..........28.40%
Phyto menadione dry powder 5% GFP..........0.19%
关键字：multivitamin tablet cores
