MultivitaminTabletswithCopperandZinc
1.Formulation
Vitaminmixture（BASF,see“Remark”）.....1000g Aerosil200[4].............................................5g Ludipress[1]...........................................150g AvicelpH102[5]......................................120g KollidonVA64[1].......................................25g Magnesiumstearate[2]..............................10g Talc[10]....................................................10g 2.Manufacturing（Directcompression）
Passallcomponentsthrougha0.8mmsieve,mixandpresswithhigh
compressionforce.
3.Tabletproperties
Weight...............................................1350mg Diameter...............................................16mm
Form...................................................biplanar
Hardness..................................................62N
Disintegration（water）...............................3min
Friability...................................................1.0%
4. Remark
The used vitamin mixture had the following composition:
Thiamine mononitrate...............................3.9%
Riboflavin 100..........................................0.4%
Nicotinamide ..........................................10.1%
Calcium D-panto thenate ..........................2.9%
Pyridoxine hydrochloride ..........................1.2%
Cyanocobalamin gelatin coated 0.1% .......2.6%
Folic acid .................................................0.1%
Ascorbic acid fine powder ......................63.4%
Vitamin E acetate dry powder 500 SD .......9.1%
Cupper oxide...........................................0.3%
Zinc sulphate ...........................................6.0%
关键字：multivitamin tablets copper
