MultivitaminTablets,DC
（1–2RDAofVitamins）
1.Formulation
No.1No.2
VitaminAacetatedrypowder......................10.0g10.0g 500000i.u./g（BASF）...........................................
Thiaminemononitrate（BASF）.........................2.2g2.2g Ribolfavin（BASF）...........................................2.2g2.2g Nicotinamide...............................................16.5g16.5g CalciumD-panto thenate（BASF）...................11.5g11.5g Pyridoxinehydrochloride（BASF）....................2.2g2.2g Cyanocobalamin0.1%drypowder.................6.0g6.0g Ascorbicacid,powder（BASF）......................85.0g85.0g VitaminEacetatedrypowderSD50...........31.0g31.0g （BASF）
Ludipress[1].............................................321.0g–
Microcrystallinecellulose,Vitacel.......................–300.0g （Rettenmaier）
KollidonVA64[1]................................................–21.0g Magnesiumstearate[2].................................3.0g3.0g Orangeflavour..............................................7.2g7.2g Saccharinsodium.........................................2.5g2.5g 2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieve,mixandpresswith
mediumcompressionforce（15kN）.
3. Tablet properties
No. 1 No. 2
Weight ......................................................500 mg 501 mg
Diameter ....................................................12 mm 12 mm
Form ........................................................biplanar biplanar
Hardness ......................................................68 N 195 N
Disintegration （water） ....................................5 min 6 min
Friability .......................................................0.2% <0.1%
4. Chemical stability of formulation No. 1 （after 12 months at 20–25 C）
Vitamin A ..............................................88%
Vitamin B6 ..............................................94%
Calcium D-panto thenate ................................92%
Vitamin B12 ..................................................... 90%
All other vitamins .........................................> 95%
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