Paracetamol（=Acetaminophen）
EffervescentTablets
（500mg）DC
1.Formulations
No.1No.2
Paracetamol,granular（BASF）......................................500g–
Paracetamol,granulatedwith3%ofpovidone.....................–525g Citricacid,finegranules（Jungbunzlauer）......................500g500g Sodiumbicarbonate（Merck）.........................................600g600g LudipressLCE[1]........................................................700g600g LutrolE4000F[1]..........................................................80g100g 2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieve,addthelubricantand
presswithhighcompressionforceof25-30kN.
3.Tabletproperties
No.1No.2
Weight..................................................2384mg2340mg Diameter.....................................................20mm20mm
Form...................................................biplanarbiplanar
Hardness......................................................125N153N
Disintegration....................................................1-2min1-2min
Friability.......................................................1.2%0.8%
4.Remark
Thesedimentationofparacetamolafterthedissolutionofthetabletin
waterismuchbetterusingthepovidonegranulatedparacetamol.
关键字：paracetamol acetaminophen effervescent
