Multivitamin Effervescent Tablets, WG

MultivitaminEffervescentTablets,Wg 1.Formulation I.Thiaminemononitrate（BASF）..................13mg Riboflavin（BASF）......................................4mg Pyridoxinehydrochloride（BASF）..............11mg Nicotinamide..........................................66mg CalciumD-panto thenate（BASF）..............17mg Tartaricacid,powder............................360mg Sodiumbicarbonate..............................550mg Sucrose,crystalline...............................300mg Sucrose,powder..................................300mg Kollidon30[1]........................................35mg II.Kollidon30...............................................5mg Isopropanol..................................about80mg III.Riboflavin（BASF）......................................6mg Ascorbicacid,powder（BASF）...............550mg Cyanocobalamin0.1%drypowder..........20mg VitaminApalmitate 250000I.U./gdrypowderCWD（BASF）...12mg VitaminEacetatedrypowder50%.........60mg Polyethyleneglycol6000,powder[6].......80mg KollidonCL[1]......................................100mg 2.Manufacturing（Wetgranulation） GranulatethemixtureIwithsolutionII,dryat60Cwithvacuum,mix withIIIandpresswithhighcompressionforce. 3.Tabletproperties Weight...............................................2500mg Diameter...............................................20mm Form...................................................biplanar Hardness................................................140N Disintegration（water）...........................1–2min Friability......................................................1%4. Chemical and physical stability （20-25 C）6 Months 12 MonthsAscorbic acid 100% 92%Cyanocobalamin 91% 92%Vitamin A 80% 69%All other vitamins > 94% > 94%Hardness 114 N 105 NDisintegration （water） < 2 min < 2 minFriability 1.6% 2.0%5. RemarkThe high loss of vitamin A is caused by the strong hardness of the thetablets. The compression force should be reduced to minimize the expressionof vitamin A from the dry powder and to increase its stability by thismanner.