Paracetamol Chewable Tablets

Paracetamol（=Acetaminophen）Chewable Tablets （300mg） 1.Formulation I.Paracetamol,milled（Hoechst）..................300g Sucrose,milled........................................600g KollidonCL-M[1].....................................550g Orangeflavour（FDO）.................................30g Strawberryflavour（FDO）............................30g II.Kollidon30[1]...........................................60g Ethanol96%.................................about425g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass throughasieveandpresswith mediumcompressionforce. 3.Tabletproperties Weight..............................................1,620mg Diameter...............................................20mm Form...................................................biplanar Hardness................................................111N Disintegration........................................27min Friability......................................................1% 4.Tasteonchewingofthetablets Sweet,fruityandonlyveryslightlybitter.