Paracetamol Effervescent Tablets

Paracetamol（=Acetaminophen） EffervescentTablets （500mg）Wg 1.Formulation I.Paracetamol,powder<300μm...............500g Sodiumbicarbonate................................500g Tartaricacid,powder...............................430g Dextrose.................................................200g Flavouring II.Kollidon30[1]...........................................20g Isopropanol...........................................100ml III.Polyethyleneglycol6000,powder[6]..........60g 2.Manufacturing（Wetformulation） GranulatethemixtureIwithsolutionII,pass througha0.8mmsieve, addIII,mixandpressto tablets. 3.Tabletproperties Weight..............................................1,700mg Diameter...............................................16mm Form...................................................biplanar Hardness................................................150N Disintegration..........................................4min Friability...................................................0.7%