VitaminC（Ascorbicacid）Effervescent
Tablets
（100mgand1000mg）
1.Formulation
No.1No.2
100mg1000mg Ascorbicacid,powder（BASF）.......................112g–
Ascorbicacid,crystalline（BASF）..........................–1000g Sorbito l,crystalline[10].......................................–800g Sorbito lInstant（Merck）.................................200g–
Citricacid,anhydrous.................................1000g150g Sodiumbicarbonate.....................................587g660g Polyethyleneglycol6000,powder[6]..............65g80g Lemonflavour................................................10gq.s.
Cyclamatesodium..........................................25gq.s.
Saccharinsodium............................................1gq.s.
2.Manufacturing（Directcompression）
Drythesodiumbicarbonateduring1hourat100C,mixwiththeother
components,pass allthrougha0.8mmsieveandpresswithhigh
compressionforceatmaximum30%ofrelativeatmospherichumidity.
3.Tabletproperties
No.1No.2
Weight....................................................2050mg2,690mg Diameter....................................................20mm20mm
Form........................................................biplanarbiplanar
Hardness.....................................................150N174N
Disintegration（water）...............................2–3min2–3min
Friability.....................................................<0.1%0.8%
关键字：vitamin effervescent tablets
