Beta Carotene Vitamin C Beta Carotene Vitamin C

BetaCarotene VitaminC
VitaminETablets
（6mg 100mg 30mg）
1.Formulations
No.1No.2
Betavitdrypowder10%（BASF）...................65g65g Ascorbicacid,powder（BASF）.......................100g100g VitaminEacetatedrypowder50%................60g60g Ludipress[1]................................................369g–
Sorbito l,crystalline（Merck）..................................–233g KollidonVA64[1].................................................–30g KollidonCL[1]....................................................–8g Magnesiumstearate[2]....................................6g4g 2.Manufacturing（Directcompression）
Passallcomponentsthrougha0.8mmsieve,mixandpresswith
mediumorhighcompressionforce.
3.Tabletproperties
No.1No.2
Weight......................................................599mg502mg Diameter....................................................12mml2mm
Form........................................................biplanarbiplanar
Hardness......................................................60N59N
Disintegration（water）....................................7min7min
Friability.......................................................0.3%0.2%
4.ChemicalstabilityofbetacaroteneinFormualtionNo.1
（40C,closed）
0weeks15weeks
Betacarotene/tablet8.0mg7.8mg 5.Remarks
Acolourantpigmentshouldbeaddedto obtainahomogeneousappearance
ofthetablets.
ThetabletsofFormulationNo.1couldbecommercializedinEuropeas
dietaryfoodbecauseallcomponentsareallowedforthisapplication.