Vitamin A Vitamin D3 Vitamin E Beta Carotene Veterinary Injectable Solution

VitaminA VitaminD3 VitaminE Beta CaroteneVeterinary Injectable Solution （100000i.u. 20000i.u. 10mg 8mg/g） 1.Formulation I.VitaminApropionate................................4.4g 2.5Mioi.u./g（BASF） VitaminD340Mioi.u./g..........................0.05g Benzylalcohol..........................................1.0g CremophorEL[1].....................................9.0g II.WaterforInjectable s...............................72.3g III.VitaminEacetate....................................1.0g Butylhydroxyto luene.................................0.4g CremophorEL[1]...................................<9.0g IV.Beta-Carotenecrystalline（BASF）...............0.8g 2.Manufacturing HeatmixtureIto 65C.HeatthewaterIIto 65Candadditslowlyto theheatedmixtureI.AclearSolution isformed（=MixtureI/II）. HeatthemixtureIIIto 180C.Whenthetemperatureisreachedaddthe beta-caroteneIV,holdfor3minatthistemperatureandthenadd MixtureI/IIslowlyduringthenext4minutes.Letcoolundercontinuous stirringofabout30minutes.AclearSolution isformed. Aftertheampouleshavebeenheat-sterilized,theyshouldbeshakenfor ashorttime,whiletheyarestillhot,to eliminateanyseparationofthe phasesthatmayhaveoccurred.Sterilizationcanalsobeperformedby membranefiltrationunderpressure. 3.PropertiesoftheSolution Darkred-brown,clearSolution . 4.Remark InGermanyCremophorELmustbedeclaredonthepackageof Injectable s.