Multivitamin Instant Granules

MultivitaminInstantGranules （2–4RDAofVitamins） 1.Formulation I.VitaminA Ddrypowder250000 50000I.U./gCWD（BASF）....................200g Thiaminemononitrate（BASF）.....................26g Riboflavin（BASF）.......................................33g Nicotinamide...........................................110g Pyridoxinehydrochloride（BASF）.................22g CalciumD-panto thenate（BASF）...............150g Cyanocobalamin0.1%...............................66g gelatincoated（BASF） Ascorbicacidpowder（BASF）................1,150g VitaminEacetatedrypowder...................210g SD50（BASF） Sucrose,finelyground........................20000g KollidonCL-M[1]..................................5000g Orangeflavour......................................1000g II.KollidonVA64[1].................................2000g EthanolorIsopropanol.....................approx.7l 2.Manufacturing Passmixturethrougha0.8mmsieveandgranulatewithsolutionIIinthe fluidizedbed.Fill6–12gofthegranulesinsachets. Ifthetechnologyofafluidizedbedisnotavailable,thedrypowdersof vitaminA,EandB12shouldbeaddedafterthegranulationoftheother components. 3.Administration Suspend 6–12g（=1sachet）inaglassofwatercorrespondingto 2–4 RDAofvitamins.4. Properties of the suspensionThe multivitamin suspension is prepared prior to application by shakingthe granules with water. The uniform, yellow suspension thus obtainedshows no sedimentation over a period of some hours. The redispersibilityis very easy.5. Stability （after 12 months, 20–25 C, HPLC）Vitamin C..................................................91%Calcium panto thenate .......................not testedAll other vitamins ....................................> 95%