Multivitamin Oral Gel with Linoleic Acid and Linolenic Acid

MultivitaminOralGelwithLinoleicAcidand LinolenicAcid 1.Formulation I.EveningPrimroseOil（Epopure, PrimaRosa/SA）......................................5.0ml VitaminApalmitate.................................30mg 1.7Mio.i.u./g（BASF） VitaminEacetate（BASF）.........................19mg VitaminD340Mioi.u./g.........................150μg CremophorRH40[1]..............................20.0g II.Water.....................................................55.0g III.Thiaminehydrochloride（BASF）..................3mg Riboflavin（BASF）......................................3mg Pyridoxinhydrochloride（BASF）................15mg Cyanocobalamin,crystalline.....................10μg CalciumD-panto thenate（BASF）..............10mg Nicotinamide..........................................50mg Ascorbicacid,crystalline（BASF）...............1.0g LutrolF127[1].......................................14.0g IV.LutrolF127[1].........................................5.0g to talamount:.................................about100g 2.Manufacturing PreparemixtureIandheatto about65C.AddthewarmwaterII（65C） slowlyto thewellstirredmixtureI.Dissolveat20–25Cthecomponents IIIinthisclearsolutionI/ II.Cooltheobtainedsolutionto about 5Canddissolvetheresto fLutrolF127（=IV）.Maintainthecool temperatureuntiltheairbubblesescaped. 3.Properties Aclearyellowgelwasobtained.4. Remark5 ml of Evening Primrose Oil Epopure contains 3.5 g linoleic acid and0.45 g gamma-linolenic acid.