MiconazoleMouthGel (2%) 1.Formulation I.Miconazolenitrate(Sigma)........................2.0g Orangeflavour..........................................0.1g
II.LutrolF127[1].......................................20.0g CremophorRH40[1]..............................10.0g Propyleneglycol[1].................................10.0g III.Kollidon90F[1].......................................5.0g Saccharinesodium...................................0.3g Water.....................................................52.6g 2.Manufacturing DissolveIinthemoltenmixture
II.HeatsolutionIIIto 90Candmix slowlywithI/
II.Letcoolto roomtemperaturewhentheairbubbles escaped. 3.Propertiesofthegel Acolourless,clearandsoftgelwasobtainedhavingaorangeliketaste andaslightlybitteraftertaste.
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