Piroxicam DexpanthenolGel
（0.5% 5.0%）
1.Formulation
Piroxicam（Sigma）.....................................0.5g 1,2-Propyleneglycol[1]..........................25.0g Dexpanthenol（BASF）................................5.0g Ethanol96%............................................5.0g Triethanolamine...............................about0.4g LutrolF127[1].......................................23.0g Water.....................................................46.0g 2.Manufacturing Firstmodeofpreparation:
Preparethesolutionofpiroxicaminpropyleneglycolanddexpanthenol
at70–80C,addethanolandLutrolF127.Stirrthehighlyviscous
mixture,add50%ofthehotwater（70C）,adjust thepHwithtriethanolamine
to about7,addtheresto fthewater,coolto roomtemperature
whentheairbubblesescapedandadjust thepHto about8.
Alternativemodeofpreparation:
Dissolvepiroxicaminpropyleneglycol,dexpanthenolandtriethanolamine.
CoolthemixtureofLutrolF127andwaterto about5Candmixwith
thepiroxicamsolution.Addtheethanol.Maintainthecooltemperature
untiltheairbubblesescaped.
3.Propertiesofthegel
AclearcolourlessgelwasformedhavingapHofabout8.
4.Remark
Theadditionofethanolisnotessentialbecauseitreducestheviscosity.
关键字：piroxicam dexpanthenol gel
