Povidone-Iodine Lidocain Gel

Povidone-Iodine LidocainGel （10%） 1.Formulation I.PVP-Iodine30/06（BASF）........................10.0g Lidocainhydrochloride..............................1.0g Sodiumchloride.......................................1.0g II.LutrolF127[1].......................................20.0g III.Sodiumhydroxidesolution,1molar...........7.9g IV.Water.....................................................61.1g 2.Manufacturing Dissolvethesolids（I）inwater（IV）,coolto about6C,dissolveLutrolF 127（II）andadjust thepHvaluewiththesodiumhydroxidesolution（III）. Maintainthecooltemperatureuntiltheairbubblesescaped. 3.Propertiesofthegels Viscosity（Brookfield,23C）........54000mPas pHvalue（20%inwater）..............................4.7 4.Stability（14days,52C） Viscosity（Brookfield,23C）.........51000mPa.s pHvalue（20%inwater）..............................2.4 Lossofavailableiodine...........................15.5%