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Povidone-Iodine( Lidocain) Thermo-GellingSolution (10%) 1.Formulations withoutwith lidocainlidocain I.PVP-Iodine30/06(BASF).............................10.0g10.0g Lidocainhydrochloride........................................–1.0g Sodiumchloride............................................1.0g0.7g II.LutrolF127[1]............................................15.0g15.0g III.SodiumhydroxideSolution ,1molar................4.4g4.2g IV.Water.........................................................69.6g69.1g 2.Manufacturing Dissolvethesolids(I)inwater(IV),coolto about6C,dissolveLutrolF 127(II)andadjust thepHvaluewiththesodiumhydroxideSolution (III). 3.Propertiesofthegels Viscosityatroomtemperature.....viscousSolution s (20–25C) Viscosityontheskin(35–37C).....................gels pHvalue(20%inwater)...................................4.8 4.Stability(14days,52C) withoutwith lidocainlidocain pHvalue(20%inwater)...................................2.52.9 Lossofavailableiodine.................................9.7%20%5. RemarkSince the stability of the combination of Povidone-Iodine with lidocaineis limited the formulation No. 2 is mainly provided for the production anduse in hospitals.
关键字:povidone iodine thermo
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