Povidone-Iodine Solution

（10%）,I
1.Formulations
No.1No.2
PVP-Iodine30/06（BASF）.............................10.0g10.0g LutrolF127[1]...................................................–0.3g LutrolE400[1]...................................................–0.5g Citricacid0.1molarsolution........................43.6g43.2g Na2HPO412H2O0.2molarsolution..........46.4g46.0g 2.Manufacturing DissolvethePVP-Iodine（andLutrolF127）inthemixtureofthebuffer
solutions（andLutrolE400）.
3.Propertiesofthesolutions
BrownclearsolutionshavingalowviscosityandpHofabout4.5.
4.Chemicalstability
FormulationNo.1（20–25C,1year）
0Month6Months12Months
Availableiodine100%100%96%
pH4.44.14.4
FormulationNo.2（52C,14days）
Lossofavailableiodine6.3%