TheophyllineInjectable Solution
（4%=200mg/5ml）
1.Formulation
Theophylline（Knoll）.....................................2g Kollidon12PF[1]......................................15g Propyleneglycol[1]...................................10g Preservative...............................................q.s.
Antioxidant.................................................q.s.
WaterforInjectable s.............................ad50g 2.Manufacturing DissolveKollidon12PFandthepreservative/antioxidantinwaterand
addtheophyllineto thewellstirredSolution
3.PropertiesoftheSolution
TheobtainedclearandsomewhatyellowishSolution hadgotthepH
value5.2anddidnotrecrystallizeinashorttermtest.
4.Remarks
to prevento fdiscolourationofKollidonintheSolution duringsto rage0.2
to 0.5%ofcysteinecouldbeaddedasantioxidant.
关键字：theophylline injectable solution
