Metronidazole Injectable Solution

MetronidazoleInjectable Solution （500mg/10ml） 1.Formulation I.Metronidazole..........................................5.0g II.Kollidon12PF[1]...................................25.0g Propyleneglycol[1]................................25.0g LutrolE400[1].......................................25.0g WaterforInjectable s...............................20.0g III.Hydrochloricacid0.1N..............................q.s. 2.Manufacturing Suspend IintheSolution II,adjust pH4.4withIIIandheatuntilmetronidazol isdissolved. 3.PropertiesoftheSolution AclearSolution wasobtained.Itcanbedilutedwithwaterwithout precipitation. 4.Remark to prevento fdiscolourationofKollidonintheSolution duringsto rage0.2 to 0.5%ofcysteinecouldbeaddedasantioxidant.