Oxytetracycline Injectable Solution for i. m. i. v. Veterinary Application

Oxytetracycline Injectable Solution for i.m. i.v.Veterinary Application （500mg/10ml） 1.Formulation I.0xytetracycline hydrochloride...................5.7g II.Kollidon17PF[1]...................................10.0g Reducingagent........................................0.5g （e.g.RongaliteC,BASF） WaterforInjectable s..........................ad100ml III.Magnesiumoxide...................................0.46g IV.Ethanolamine...........................to adjust pH8.8 2.Manufacturing Suspend IIIinSolution II,pass continously nitrogen through the Solution to avoidoxidationandaddslowlyIto thewellstirredSolution .adjust the pHwith IV. 3.PropertiesoftheSolution YellowclearSolution . 4.Remarks Theabsenceofoxygenduringmanufacturingandinthefinalpackaging andagoodqualityofOxytetracycline HClareessentialto avoidthe oxidation（=darkSolution ）. ThefunctionofKollidon17PFnoto nlyisthesolubilisationofOxytetracycline butalsothereductionofitslocalto xicity. Thereducingagentmustbeselectedinaccordancewiththelegislation ofthecorrespondingcountry.