Metronidazole Effervescent Vaginal Tablets

（500mg） 1.Formulation I.Metronidazole.........................................500g Sodiumbicarbonate................................600g Kollidon30[1]...........................................30g II.Kollidon30[1]...........................................10g Isopropanol...........................................150ml III.Tartaricacid,crystalline............................500g Polyethyleneglycol6000,powder[6]..........50g 2.Manufacturing（Wetgranulation） GranulateIwithsolutionII,pass througha0.8mmsieve,mixwithIIIand press. 3.Tabletproperties Weight................................................1700mg Diameter...............................................16mm Form...................................................biplanar Hardness................................................113N Disintegration..........................................4min Friability...................................................1.8%