TheophyllineSustainedReleaseTablets
（400mg）,Wg 1.Formulations
No.1No.2
ITheophylline,powder（BASF）........................400g400g Granulac140[8]...........................................337g356g IIKollicoatSR30D[1]......................................198g–
KollicoatEMM30D[1]..........................................–132g IIIAerosil200[4]..................................................4g4g Magnesiumstearate[2]....................................4g4g 2.Manufacturing（Wetgranulation）
GranulatethemixtureIwithKollicoatSR30DorKollicoatEMM30D（II）in
afluidizedbed（inlettemperature45-55C,outlettemperature21-25C,
nozzle0.8mm,spraypressure1.5-2.0bar,sprayrate10g/min）,mix
withthecomponentsofIIIandpressto tabletswithmediumcompression
force.
3.Tabletproperties
Percento fKollicoat（solidpolymer）............7.4%5.0%
Weight.................................................797mg811mg Diameter........................................19x8.5mml9x8.5mm
Form.....................................................oblongoblong Hardness................................................276N228N
Friability...................................................0.1%<0.1%
关键字：theophylline sustained release
