SustainedReleaseCoatingofPropanolol
PelletsII
1.Formulation
IPolymerSuspension:
KollicoatEMM30D[1].........................393.0g Water.................................................221.3g IIPigmentSuspension:
Kollidon30[1]........................................5.0g SicovitIronoxideRed30[1]....................5.0g Talc[10]...............................................47.2g Pharsil21046VP[Wacker]....................70.9g Water.................................................257.6g to talI II:.............................................1000g SolidContentI II:....................................246g IIIPropanololHCIspheronizedpellets30%
（Seechapter5.4）...................................1000g IVAntitacksuspension:
Aerosil200[4].............................................1g Water........................................................60g 2.Manufacturingofthesuspension
IDilutetheKollicoatsuspensionwithwater.
IIDissolveKollidon30inwater,suspendtheironoxidepigmentandtalc
andhomogenizeinacolloidmill.ThenaddPharsil21046VP.
AddthepigmentsuspensionIIto thewellstirredpolymersuspensionI.
Stirtheobtainedsuspensionduringtheentirecoatingprocess.
3. Coating procedure （Fluidized bed Aeromatic MP-1）
Loading of propanolol pellets （III） ..................................................1 kg
Nozzle ...................................................................................0.8 mm
Spraying pressure ......................................................................1 bar
Inlet air .........................................................................100-120 m3/h
Inlet temperature..................................................................40-45 C
Pellet temperature................................................................28-31 C
Outlet temperature ...............................................................28-30 C
Spray rate .........................................................................7-11 g/min
Drying time after coating ............................................................5 min
Antitack suspension after coating ................................................61 g
关键字：sustained release coating
