Sustained Release Coating of Propanolol Pellets I

SustainedReleaseCoatingofPropanolol
PelletsI
1.Formulation
IPolymerSuspension:
KollicoatSR30D[1].............................249.4g 1,2-Propyleneglycol[1]..........................7.5g Water.................................................174.6g IITalcSuspension:
Talc[10]...............................................29.9g Water...................................................44.9g to talI II:............................................506.3g IIIPropanololHCIspheronizedpellets20%
（Seechapter5.4）....................................500g 2.Manufacturingofthesuspension
IMixpropyleneglycolwithwaterandSuspend slowlyKollicoatSR30D.
IISuspend thetalcinwaterandhomogenizeinacolloidmill.
AddthetalcsuspensionIIto thewellstirredpolymersuspensionI.Stir
theobtainedsuspensionduringtheentirecoatingprocess.
3. Coating procedure （Fluidized bed Aeromatic Strea-1）
Loading of propanolol pellets 20 % （III） ........................................500 g
Quantity of spray suspension applied ......................506 g = 3 mg/cm2
Nozzle ...................................................................................0.8 mm
Spraying pressure ......................................................................1 bar
Inlet air .................................................................................80 m3/h
Inlet temperature.......................................................................60 C
Pellet temperature.....................................................................36 C
Outlet temperature ....................................................................35 C
Spray rate ..............................................................................3 g/min
Spray pressure........................................................................1.2 bar
Spray time...............................................................................39 min
Drying time after coating （45 C）.................................................5 min