Tramadol Sustained Release Tablets

（100mg）
1.Formulation
Tramadol-HCI（Chemagis）......................100.0g KollidonSR[1]......................................150.0g Silicondioxide,colloidal............................2.5g Magnesiumstearate[2].............................1.5g 2.Manufacturing（Directcompression）
Allingredientswerepass edthrougha0.8mmsieve,blendedfor10min
inaTurbulamixerandthencompressedwithmediumcompression
force.
3.Tabletproperties
Diameter...............................................10mm
Weight.................................................254mg Hardness................................................211N
Friability.....................................................0%