SustainedReleaseCoatingofDiclofenac
Pellets
1.Formulation
IPolymerSuspension:
KollicoatEMM30D[1]..........................224.1g IITalcSuspension:
Talc[10]...............................................29.3g Water.................................................228.8g to talI II:............................................482.2g SolidContentI II:.......................96.5g（=20%）
IIIDiclofenacsodiumspheronized
pellets30%（seeChapter5.4）.................500g 2.Manufacturingofthesuspension
AddthetalcsuspensionIIto thewellstirredpolymersuspensionI.Stir
theobtainedsuspensionduringtheentirecoatingprocess.
3.Coatingprocedure,to pspray（FluidizedbedAeromaticStrea-1）
Loadingofdiclofenacpellets......................................................500g Quantityofspraysuspensionapplied.........................................482g Quantityofsolidsapplied............................................................97g Quantityofpolymerapplied.................................................4mg/cm2
Nozzle...................................................................................0.8mm
Sprayingpressure......................................................................1bar
Inlettemperature.......................................................................50C
Outlettemperature....................................................................33C
Airvolume.............................................................................80m3/h
Sprayrate............................................................................14g/min
Spraypressure........................................................................1.2bar
Spraytime...............................................................................35min
Dryingtime....................................................................5min（45C）
关键字：sustained release coating
