Povidone-IodineCream (10%) 1.Formulation I.PVP-Iodine30/06(BASF)........................10.0g Citricacidsolution0.1molar...................24.1g Na2HPO4solution0.2molar...................36.9g
II.CremophorA6[1]....................................2.0g CremophorA25[1]..................................2.0g Cetylstearylalcohol.................................10.0g Liquidparaffin.........................................10.0g Glycerol...................................................5.0g 2.Manufacturing Prepareabasiccreamfromtheemulsifyingagentsandthefatty substances(II).StirinthePVP-iodinedissolvedinthebuffersolutions(I). 3.Propertiesofthecream BrowncreamhavingapHof4.5. 4.Chemicalstability AfterproductionAfter14days/52C pH4.54.1 Availableiodine1.09%0.99% Lossofiodine–9.2% Duringthisstresstestat52Ctheemulsionwasseparatedinto two phases.
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