ClotrimazoleCream （1%） 1.Formulation I.Cetylstearylalcohol...................................7.0g CremophorA6[1]....................................1.5g CremophorA25[1]..................................1.5g Liquidparaffin........................................12.0g Parabene（s）..............................................0.2g
II.Water.....................................................68.8g III.Propyleneglycol[1]..................................8.0g Clotrimazole.............................................1.0g 2.Manufacturing HeatthemixtureIandthewaterIIseparatelyto about80C.Addthe waterIIto theobtainedsolutionIwithrigorousstirring.HeatIIIuntilthe activeingredientisdissolved,mixwithI/IIandcontinueto stirduring coolingto roomtemperature. 3.Properties Whitecream. 4.Physicalstability Nochangeofappearanceorcrystallizationwereobservedduring6weeks at45C. 5.Remark Thisformulationcouldbeusedforotheractiveingredientsto o.
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