Basic Cream for Different Active Ingredients

BasicCreamforDifferentActiveIngredients 1.Formulation I.Cetylstearylalcohol...................................7.0g CremophorA6[1]....................................1.5g CremophorA25[1]..................................1.5g Liquidparaffin........................................12.0g Parabene（s）..............................................0.2g II.Water...........................................67.8–69.7g III.Propyleneglycol[1]..................................8.0g Activeingredient...............................0.1–2.0g 2.Manufacturing HeatthemixtureIandthewaterIIseparatelyto about80C.Addthe waterIIto theobtainedsolutionIwithrigorousstirring.HeatIIIuntilthe activeingredientisdissolved,mixwithI/IIandcontinueto stirduring coolingto roomtemperature. Thisbasiccreamwastestedwithdifferentactiveingredientssolublein 1,2-propyleneglycol. 3.Properties Whitecream. 4.Physicalstability Nochangeofappearancewereobservedduring6weeksat45C.