Vitamin A Vitamin D3 Calcium Magnesium Injectable Solution

VitaminA VitaminD3 Calcium Magnesium Injectable Solution （33000i.u. 6000 i.u. 100mg 200mg/gi.u.） 1.Formulation I.VitaminApalmitate1.7Mioi.u./g（BASF）..2.0g VitaminD3（Cholecalciferol）40Mio.i.u./g15mg Soluto lHS15[1].....................................13.0g II.WaterforInjectable s...............................85.0g III.Calciumgluconate....................................1.1g Magnesiumsulfate...................................1.0g 2.Manufacturing HeatmixtureIandthewater（II）separatedto about65C.Addthe waterveryslowlyto thewellstirredmixtureI.Coolto roomtemperature anddissolvethecomponentsIII. Aftertheampouleshavebeenheat-sterilized,theyshouldbeshakenfor ashorttime,whiletheyarestillhot,to eliminateanyseparationofthe phasesthatmayhaveoccurred.Sterilizationcanalsobeperformedby membranefiltrationunderpressure. 3.PropertiesoftheSolution s AclearyellowSolution wasobtained. 4.Physicalstability（20–25C,protectedfromlight） Nochangeoftheclarityaftersomedays. 5.Remark Perhapsitwouldberecommendableto useanothermagnesiumsalt insteadofthesulfateto avoidanyprecipitationofcalciumsulfateduring sto rage.