VitaminBComplex VitaminCTablets
1.Formulations
No.1No.2
Thiaminemononitrate（BASF）.........................5.0g–
Thiaminehydrochloride（BASF）............................–15.0g Riboflavin（BASF）...........................................5.0g2.0g Pyridoxinehydrochloride（BASF）....................5.0g5.0g Folicacid......................................................0.5g–
Cholinebitartrate................................................–25.0g Niacin.........................................................30.0g–
Nicotinamide.......................................................–10.0g Biotin（Merck）................................................0.1g–
CalciumD-panto thenate（BASF）...................10.0g–
Ascorbicacid,..........................................150.0g100.0g crystalline/powder（BASF）
Ludipress[1].............................................172.4g220.0g KollidonVA64[1]........................................20.0g–
Magnesiumstearate[2].................................2.0g–
Stearicacid[7]....................................................–8.0g 2.Manufacturing（Directcompression）
Weighallingredientsin,pass througha0.8mm-sieveandmix.Pressthe
mixturewithmedium/lowcompressionforce.
3. Tablet properties
No. 1 No. 2
Weight ......................................................400 mg 411 mg
Diameter ....................................................10 mm 12 mm
Form ........................................................biplanar biplanar
Hardness ......................................................95 N 69 N
Disintegration ..........................................3 – 4 min 5 min
Friability........................................................0.1% 0.3%
4. Remark
For stability reasons it would be better to substitute thiamine hydrochloride
by thiamine mononitrate in formulation No. 2.
关键字：vitamin complex
