Paracetamol（=Acetaminophen）Syrup
（5%=500mg/10g）
1.Formulation
Paracetamol（BASF）.................................5.0g Sorbito l,crystalline[10].............................5.0g Cyclamatesodium....................................4.0g Strawberryflavour....................................0.1g Kollidon25[1]........................................20.0g Glycerol.................................................15.0g 1,2-Propyleneglycol[1]..........................20.0g Water.....................................................31.0g 2.Manufacturing DissolvefirstKollidon25andthentheothersolidcomponentsinthe
solventmixtureofglycerol,propyleneglycolandwater.
3.Propertiesofthesyrup
Clearsolutionofcertainviscosityhavingonlyaslightlybittertaste.
4.Physicalstability
Thesolutionremainedclearduringmorethan1weekat6Candduring morethan3monthsat25Cand40C.
Thecolourofthesolutionchangedonlyalittleduring3monthsat25C
and40C.to prevento fdiscolourationduringsto rage0.2to 0.5%of
cysteinecouldbeaddedasantioxidant.
5.Chemicalstability（HPLC）
Nolossofparacetamolwasfoundduring3monthsat40C.
关键字：paracetamol syrup
