TerfenadineSuspension
(1.2%=60mg/5ml)
1.Formulation
Terfenadine..............................................1.2g LutrolF127[1].........................................3.0g CremophorRH40[1]...............................3.6g Preservative...............................................q.s.
Water.....................................................92.2g 2.Manufacturing DissolveLutrolF127andCremophorRH40inwaterat40C.Whilst
stirringslowlyaddtheterfenadine.
3.Propertiesofthesuspension
Atastelessmilkysuspensionwasobtained.
4.Physicalstability
After7daysofsto rageatroomtemperaturealmostnosedimentationof
theterfenadinewasobservedbuttheredispersibilitybyshaking(2times)
wasveryeasy.
关键字:terfenadine suension