Propanolol Spheronized Pellets for Sustained Release Coating

PropanololSpheronizedPelletsforSustained
ReleaseCoating（20%and30%）
1.Formulations
20%Pellets30%Pellets
IPropanololHCI.............................................200g300g AvicelpH101[5]...........................................517g467g Granulac230[8]..........................................258g208g KollidonVA64[1]............................................25g25g IIWater.................................................about500g540g 2.Manufacturing Granulatethemixture（I）inaDiosnagranulato rwithwater（II）andpress
thehumidgranulesthroughasieveof1.5mm.Formpelletsinaspheronizer
withtherotationspeedof200-400rpm.Drythepelletsinafluizid
bedandsievethrougha0.7mmsieveto eliminatethefineparticles.
3.Remark
Seealso“SustainedReleaseCoatingofPropanololPellets”