Alpha-MethyldopaTabletCores
(250mg),DC
1.Formulation
Alpha-Methyldopa...................................250g Ludipress[1]...........................................350g Stearicacid[7]..........................................15g 2.Manufacturing(Directcompression)
Mixallcomponents,pass througha0.8mmsieveandpresswithlow
compressionforce.
3.Tabletproperties
Weight.................................................620mg Diameter...............................................11mm
Form..................................................biconvex
Hardness................................................123N
Disintegration..........................................6min
Friability...................................................0.2%
Dissolution(10min)...................................91%
(20min)...................................98%
4.Physicalstability(20months,20–25C)
Weight.................................................620mg Hardness................................................115N
Disintegration..........................................7min
Friability...................................................0.5%
Dissolution(10min)...................................91%
(20min).................................100%
BASF
关键字:甲基