Povidone-Iodine Thermo-Gelling Solution

Povidone-Iodine（ Lidocain） Thermo-GellingSolution （10%） 1.Formulations withoutwith lidocainlidocain I.PVP-Iodine30/06（BASF）.............................10.0g10.0g Lidocainhydrochloride........................................–1.0g Sodiumchloride............................................1.0g0.7g II.LutrolF127[1]............................................15.0g15.0g III.SodiumhydroxideSolution ,1molar................4.4g4.2g IV.Water.........................................................69.6g69.1g 2.Manufacturing Dissolvethesolids（I）inwater（IV）,coolto about6C,dissolveLutrolF 127（II）andadjust thepHvaluewiththesodiumhydroxideSolution （III）. 3.Propertiesofthegels Viscosityatroomtemperature.....viscousSolution s （20–25C） Viscosityontheskin（35–37C）.....................gels pHvalue（20%inwater）...................................4.8 4.Stability（14days,52C） withoutwith lidocainlidocain pHvalue（20%inwater）...................................2.52.9 Lossofavailableiodine.................................9.7%20%5. RemarkSince the stability of the combination of Povidone-Iodine with lidocaineis limited the formulation No. 2 is mainly provided for the production anduse in hospitals.