IbuprofenSuspension
(4%=400mg/10ml),I
1.Formulation
Ibuprofen(BASF).........................................4g Sucrose....................................................25g KollidonCL-M[1]........................................8g Kollidon90F[1]..........................................2g Sodiumcitrate.............................................2g Water................................................ad100ml
2.Manufacturing Dissolvesucrose,Kollidon90Fandsodiumcitrateinabout40mlof
water,suspendKollidonCL-Mandibuprofeninthissolutionbystirring andaddtheresto fwater.
3.Suspensionproperties
Color.......................................................white
Aspect.......................................Homogeneous
Viscosity.....................................................low
Rel.sedimentvolume..............................100%
(after1day)
Rel.sedimentvolume................................94%
(after4weeks)
Redispersibility...................................veryeasy
(after4weeks)
关键字:ibuprofen suension