PropranololHClSubstained-ReleasePellets
ReleasingTablets（MUPS-Formulation）
a）Formulation
Theformulationisdesignedfor500goftablets:
PropranololHCl/KollicoatSR30Dpellets......250.0g Microcrystallinecellulose
Vivapur200[7].............................................250.0g Magnesiumstearate[8].......................................2.5g b）Procedure
Mixtheingredientsto gether,pass througha0.8mmsieveandcompress
into tabletswithaforceofabout15kN.
Tabletpress....................KorschEK0,30tablets/min
Compressionforce.............................................15kN
c）Tabletproperties
Weight............................................................400mg Diameter..........................................................10mm
Form.............................................................biplanar
Hardness......................................................82-112N
*Thepelletsaremanufacturedusingthesparysuspensiondescribedinchapter4.5.3under
AmbroxolHCISubstained-releasepellets（drug-layeringprocess）
关键字：propranolol hcl substained
