SimethiconeInstantGranules
（60mgand120mg）
1.Formulation
I.Simethicone（Abil200,Goldschmidt）.....10.0g CremophorRH40[1]...............................5.0g
II.KollidonVA64[1].....................................3.0g Ethanol..................................................40.0g III.Sorbito l,crystalline（Merck）.....................50.0g Fructo se（Merck）....................................50.0g KollidonCL-M[1]....................................50.0g Orangeflavour（Dragoco）..........................0.5g 2.Manufacturing IntroducesolutionIIinto themixtureI.GranulatethepowdermixtureIII
withthewellstirredmixtureI/II,dryandpass througha1mmsieve.
Fill1or2ginsachets.
3.Propertiesofthegranules
–Freeflowingwhitegranules;
–98%coarserthan50μm;
–Easilydispersibleincoldwaterwithoutanyphysicalseparationduring 30min.
4.Administration
Takethecontento fonesachet（1g=60mgsimethiconeor2g=120mg simethicone）aspowderordispersetherecommendedamount（e.g.1to
2g）in100mlofdrinkingwater.
关键字：simethicone instant granules
